Fox has set a Sunday, January 4, 2026 premiere date for Best Medicine, a new dramedy based on the international hit Doc Martin. The one-hour series stars The Good Wife‘s Josh Charles, who moves to a small town and prefers to keep to himself. The trailer shows that isn’t going to be easy.
The series will move to its normal time period of Tuesdays at 8pm ET/PT beginning January 6th.
Season one stars Josh Charles as Dr. Martin Best, Annie Potts (Young Sheldon) as Aunt Sarah, Josh Segarra (Sirens) as Sheriff Mark Mylow, and Cree (Twinless) as Elaine Denton. Doc Martin‘s Martin Clunes is a special guest star, playing Martin Best’s father, Dr. Robert Best.
The series also features recurring guest stars Didi Conn as councilwoman Geneva Potter, Clea Lewis as pharmacist Sally Mylow, Stephen Spinella as Greg Garrison, Jason Veasey as George Brady, Cindy De La Cruz as Jeannie, John DiMaggio as Bert Large, and Carter Shimp as Al Large. Wattson guest stars as “the stray but loveable Copernicus.”
Fox offers this lengthy description of Best Medicine:
“The series follows Martin Best (Charles), a brilliant surgeon who abruptly leaves his illustrious career in Boston to become the general practitioner in a quaint East Coast fishing village where he spent summers as a child. Unfortunately, Martin’s blunt and borderline rude bedside manner rubs the quirky, needy locals the wrong way, including schoolteacher Louisa Gavin (Spencer). He quickly alienates the town, even though he’s all they have.
Although Martin can expertly address any medical ailment or mystery in this idiosyncratic town, he’s really just desperate to be left the hell alone. Instead, he keeps getting dragged smack into the middle of their personal chaos, feuds, and fantasies. What the locals don’t know is that Martin’s terse demeanor masks a debilitating new phobia and deep-seated psychological issues that prevent him from experiencing true intimacy with anyone. But tenacity is the creed of everyone in their small village, and the people who live there may be exactly what the doctor ordered.”
Liz Tuccillo guides the series as showrunner and executive producer. Additional executive producers include Ben Silverman, Rodney Ferrell, Howard T. Owens, Mark Crowdy, Philippa Braithwaite, Jay Karas, and Tyson Bidner.
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