A bomb squad truck was destroyed from the blast, and first responders were at the scene treating injured residents, aerial footage from AIR7 HD showed.
Earlier in the day, the Los Angeles Police Department seized at least 5,000 pounds of illegal fireworks from a home.
LAPD said it is not immediately known what caused the blast, saying in a tweet that some of the fireworks were being stored in the bomb squad trailer as a precautionary measure.
Police say they discovered the massive cache at a home near 27th and San Pedro streets after Newton Division officers received a tip.
WATCH: Video captures explosion of fireworks cache in South Los Angeles
LAPD says at least 5,000 pounds of fireworks and other homemade explosives were stored in the home, which is located in a residential neighborhood near an elementary school.
A bomb squad was called to the scene to secure and remove dozens of boxes filled with fireworks, which were set to be hauled away and destroyed with the help of Cal Fire. Other fireworks and homemade explosives were planned to be destroyed on-site.
One man, identified as Arturo Cejas III, was arrested on suspicion of possessing fireworks and destructive devices and also on suspicion of child endangerment because two children were found at the home, police said.
LAPD said the fireworks had the potential of destroying multiple nearby homes if they went off, similar to a fireworks explosion at an Ontario home that killed two people in March.
The explosion prompted police to evacuate nearby residents. Prior to the blast, only two homes had been evacuated.
RELATED: Los Angeles County authorities renew warnings about illegal fireworks
The Associated Press contributed to this report.
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