Fox’s Doc returns for season two with an episode that finds a father willing to go to extreme lengths to save his daughter. Season two episode one, “Her Heart,” airs on Tuesday, September 23, 2025 at 9pm ET/PT.
Molly Parker leads the cast as Dr. Amy Larsen, Omar Metwally stars as Dr. Michael Hamda, Felicity Huffman is Dr. Joan Ridley, Amirah Vann plays Dr. Gina Walker, and Charlotte Fountain-Jardim is Katie Hamda. Jon Ecker is Dr. Jake Heller and Anya Banerjee plays Dr. Sonya Maitra.
“Her Heart” Plot: Amy’s past comes back to haunt her when a desperate father sacrifices everything to secure his daughter’s heart transplant.
Doc Series Description, Courtesy of Fox:
“Inspired by a true story and based on the hit eponymous Italian drama series, Doc begins its second season of the life-affirming medical drama following the heartbreak and victories of hard-charging, brilliant physician DR. AMY LARSEN (Parker) as she rebuilds her life after a car crash erased eight years of her memory. This season, Amy will continue to confront hard truths about her missing years, work to repair fractured relationships and seek to reconcile the person she used to be with the one everyone else has come to know.
Determined to get her memory back and piece together who she really is, Amy’s goal is to become the doctor she used to be in those missing years and to eventually, once again, be Chief of Internal Medicine. In the interim, her ex-husband/Westside Hospital’s Chief Medical Officer, DR. MICHAEL HAMDA (Metwally) fills the position with Amy’s former mentor and friend DR. JOAN RIDLEY (Huffman), whose motives and priorities remain hidden, just as long as Amy still can’t recall Joan’s life-changing secret. Amy’s best friend and colleague, DR. GINA WALKER (Vann), is weary of Joan’s motives and continues to be a beacon of support for those around her, while finally learning to put on her own oxygen mask first.
While relearning eight years of medical advancements is complicated, it pales in comparison to learning to navigate her new/old/current romantic entanglements. Amy continues to fight her feelings and let Michael go, especially now with the birth of his son with his new wife, bringing up emotions for both Amy and their daughter KATIE HAMDA (Fountain-Jardim). Amy’s on-again, off-again relationship with Chief Resident DR. JAKE HELLER (Ecker) is a bit more delicate as he struggles to protect his heart from her this time around. However, DR. SONYA MAITRA (Banerjee) would only be too glad to pick up the pieces, navigating the balance between her feelings for Jake and her complicated resentment towards Amy.
The second season of Doc begins as Amy’s past comes back to haunt her when a desperate father sacrifices everything to secure his daughter’s heart transplant. Chaos and confusion reverberate through the hallways of Westside Medical when a subsequent high-stakes emergency leaves a doctor’s life in the balance.”
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